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Heike Grassmé Selected Research

Sphingomyelin Phosphodiesterase (Sphingomyelinase)

11/2020Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D.
1/2019Acid Sphingomyelinase-Ceramide System in Bacterial Infections.
4/2018Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase.
1/2018Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.
1/2018Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin.
1/2016Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System.
1/2016Role of Janus-Kinases in Major Depressive Disorder.
1/2016Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide.
6/2015Ceramide and sphingosine in pulmonary infections.
6/2015Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
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Heike Grassmé Research Topics

Disease

23Infections
11/2020 - 06/2004
15Cystic Fibrosis (Mucoviscidosis)
01/2021 - 01/2008
8Bacterial Infections (Bacterial Infection)
01/2021 - 11/2008
5Inflammation (Inflammations)
01/2018 - 12/2010
4Pneumonia (Pneumonitis)
01/2017 - 01/2010
3Sepsis (Septicemia)
01/2017 - 07/2006
3Major Depressive Disorder (Major Depressive Disorders)
01/2016 - 01/2015
2Virus Diseases (Viral Diseases)
01/2021 - 12/2002
2Staphylococcal Infections
04/2018 - 01/2016
2Edema (Dropsy)
01/2018 - 06/2015
2Neoplasms (Cancer)
06/2015 - 06/2007
1Severe Acute Respiratory Syndrome
01/2021
1Chronic Obstructive Pulmonary Disease (COPD)
01/2018
1Acute Lung Injury
01/2018
1Persistent Infection
01/2018
1Wound Infection (Wound Infections)
01/2017
1Cardiovascular Diseases (Cardiovascular Disease)
01/2016
1Pheochromocytoma
01/2016
1Niemann-Pick Diseases (Niemann Pick Disease)
01/2016
1Bacteremia
06/2015
1Neoplasm Metastasis (Metastasis)
06/2015
1Pulmonary Edema
06/2015
1Melanoma (Melanoma, Malignant)
06/2015
1Mood Disorders (Mood Disorder)
07/2013
1Exocrine Pancreatic Insufficiency
12/2010
1Intestinal Obstruction (Obstruction, Intestinal)
12/2010
1Pseudomonas Infections
01/2010
1Hepatolenticular Degeneration (Wilson's Disease)
06/2007
1Nervous System Diseases (Neurological Disorders)
06/2007
1Communicable Diseases (Infectious Diseases)
06/2007
1Necrosis
07/2006

Drug/Important Bio-Agent (IBA)

27CeramidesIBA
01/2021 - 06/2004
18Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
11/2020 - 12/2002
16AcidsIBA
11/2020 - 12/2002
6SphingosineIBA
01/2021 - 09/2014
6SphingolipidsIBA
11/2020 - 12/2006
4Reactive Oxygen Species (Oxygen Radicals)IBA
11/2020 - 05/2010
4Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
01/2017 - 12/2010
4Antidepressive Agents (Antidepressants)IBA
01/2016 - 07/2013
4CytokinesIBA
11/2008 - 06/2004
3Proteins (Proteins, Gene)FDA Link
01/2021 - 12/2006
3Amitriptyline (Elavil)FDA LinkGeneric
01/2016 - 12/2010
2Neutralizing AntibodiesIBA
01/2018 - 07/2006
2Anti-Bacterial Agents (Antibiotics)IBA
01/2018 - 06/2015
2Phenobarbital (Luminal)FDA Link
06/2017 - 09/2014
2Death Domain ReceptorsIBA
12/2010 - 06/2007
1CeramidasesIBA
01/2021
1PlasticsIBA
01/2021
1Cathepsin DIBA
11/2020
1NADPH Oxidases (NAD(P)H oxidase)IBA
11/2020
1NADP (NADPH)IBA
11/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2018
1AntibodiesIBA
06/2017
1arginyl-glycyl-aspartic acidIBA
06/2017
1LigandsIBA
06/2017
1Janus KinasesIBA
01/2016
1MelatoninIBA
01/2016
1Tight Junction ProteinsIBA
06/2015
1dihydroceramide desaturaseIBA
06/2015
1Superoxides (Superoxide)IBA
06/2015
1IntegrinsIBA
06/2015
1Acid CeramidaseIBA
09/2014
1Fingolimod Hydrochloride (FTY720)FDA Link
09/2014
1InflammasomesIBA
01/2014
1ChloridesIBA
01/2013
1CaveolinsIBA
12/2010
1LipidsIBA
12/2010
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
05/2010
1dornase alfa (Pulmozyme)FDA Link
01/2008
1CholesterolIBA
12/2006
1Transcription Factors (Transcription Factor)IBA
12/2006
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2006
1InterleukinsIBA
07/2006
1EnzymesIBA
07/2005
1Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA
12/2002
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
12/2002

Therapy/Procedure

1Transplantation
01/2017
1Intravenous Injections
06/2015